I am going on vacation and the route I am looking at connects Indy to I-64E through Dayton onto Route 35. Is 35 a good road? Not looking for twisties just making time.

Depends on what time of day you are talking. When you hit Dayton is mostly 55 mph and I would not stray since the Dayton cops are usually out and then there are the State Highway dudes on the ramp just before I-675 and usually on the other side of Xenia. After that, you are at 65 mph (actually this happens just before you hit Xenia). However, Jim (NSX) lives out that way maybe he could give you a "get out of jail card" if you choose to speed...just kidding. It's not hateful but you really can't make much time until you are on the other side of Xenia. Hope this helps...drive safe!

Thanks for the info. the other option was 75 south to 64 east at Lexington.

That would work too (would be my choice). Cheers!